difference in regulation mechanisms of enac by aldosterone and glucocorticords不同钠由醛固酮和glucocorticords的监管机制.pdfVIP

Vol.1, No.3, 152-158 (2009) Health doi:10.4236/health.2009.13025 Difference in regulation mechanisms of ENaC by aldosterone and glucocorticords 1 2 3 3 3 3 Chengchun Tang , Hao Zhang , Su Wang , Juyou Wu , Yuchun Gu , Jeng Wei 1 st Department of Cardiology, The 1 Affiliated Hospital of Southeast University, Nanjing, China 2General Surgery, Hua Shan Hospital, China 3Department of Physiology, University of Birmingham, Edgbaston, UK; Corresponding author: y.gu@bham.ac.uk Received 11 October 2009; revised 15 September 2009; accepted 22 September 2009. ABSTRACT Single Channel Recording + Na transport occurs across many epithelial surfaces and plays a key role in regulating salt 1. INTRODUCTION and water absorption. The molecular pathway underlying this Na+ transport is the epithelial Na Active transport of Na+ across epithelial cells plays an channel (ENaC), which is strictly determined by a important role in maintenance of homeostasis of electro- variety of hormones like aldosterone, ADH and lytes and water in the body. Hormone sensitive Na+ re- glucocorticoids. In this study, we found that absorption is mainly mediated by epithelial Na+ channels stimulation of either aldosterone or dexameth- (ENaC), which are distributed in distal and collecting asone (Dex) distributed ENaC channel on the nephron ducts, and alveolar epithelial cells. Disorder of apical membrane of mouse cortical collecting EN