development of bioartificial myocardium using stem cells and nanobiotechnology templates发展人工使用干细胞心肌和纳米生物模板.pdfVIP

SAGE-Hindawi Access to Research Cardiology Research and Practice Volume 2011, Article ID 806795, 7 pages doi:10.4061/2011/806795 Review Article Development of Bioartificial Myocardium Using Stem Cells and Nanobiotechnology Templates Juan Carlos Chachques Department of Cardiovascular Surgery and Laboratory of Biosurgical Research, Pompidou Hospital, University Paris Descartes, 20 rue Leblanc, 75015 Paris, France Correspondence should be addressed to Juan Carlos Chachques, j.chachques@egp.aphp.fr Received 4 October 2010; Accepted 16 November 2010 Academic Editor: Javed Butler Copyright © 2011 Juan Carlos Chachques. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cell-based regenerative therapy is undergoing experimental and clinical trials in cardiology, in order to limit the consequences of decreased contractile function and compliance of damaged ventricles following myocardial infarction. Over 1000 patients have been treated worldwide with cell-based procedures for myocardial regeneration. Cellular cardiomyoplasty seems to reduce the size and fibrosis of infarct scars, limit adverse postischemic remodelling, and improve diastolic function. The development of a bioartificial myocardium is a new challenge; in this approach, tissue-engineered procedures are associated with cell therapy. Organ decellularization for bioscaffolds fabrication is a new investigated concept. Nanomaterials are emerging as the main candidates to ensure the achievement of a proper instructive cellular niche with good drug release/administration properties. Investigating the electrophysiological properties of bioartificial