原创力文档differential role of two-component regulatory systems (phopq and pmrab) in polymyxin b susceptibility of pseudomonas aeruginosa微分作用的双组分调节系统在多粘菌素b(phopq和pmrab)铜绿假单胞菌的敏感性.pdfVIP
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differential role of two-component regulatory systems (phopq and pmrab) in polymyxin b susceptibility of pseudomonas aeruginosa微分作用的双组分调节系统在多粘菌素b(phopq和pmrab)铜绿假单胞菌的敏感性
Advances in Microbiology, 2012, 2, 31-36
/10.4236/aim.2012.21005 Published Online March 2012 (http://www.SciRP.org/journal/aim)
Differential Role of Two-Component Regulatory Systems
(phoPQ and pmrAB ) in Polymyxin B Susceptibility of
Pseudomonas aeruginosa
1 1,2*
Daniel Owusu-Anim , Dong H. Kwon
1Department of Biology, Long Island University, New York, USA
2Department of Medicine of Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, USA
*
Email: dong.kwon@
Received January 20, 2012; revised February 4, 2012; accepted February 10, 2012
ABSTRACT
Polymyxins are often considered as a last resort to treat multidrug resistant P . aeruginosa but polymyxin resistance has
been increasingly reported worldwide in clinical isolates. Polymyxin resistance in P . aeruginosa is known to be associ-
ated with alterations in either PhoQ or PmrB. In this study, mutant strains of P . aeruginosa carrying amino acid substi-
tution, a single and/or dual inactivation of PhoQ and PmrB were constructed to further understand the roles of PhoQ
and PmrB in polymyxin susceptibility. Polymyxin B resistance was caused by both inactivation and/or amino acid sub-
stitutions in PhoQ but by only amino acid substitutions of PmrB. Alterations of both PhoQ and PmrB resulted in higher
levels of polymyxin B resistance than alteration of either PhoQ or PmrB alone. These results were confirmed by
time-killing assays suggesting that high-level polymyxin resistance in P . aeruginosa is caused by alterations of both
PhoQ and PmrB.
Keywords: Pseudomonas aerugin
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