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discontinuation of antidepressant therapy among patients with major depressive disorder停用抗抑郁治疗的重度抑郁症患者.pdf

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discontinuation of antidepressant therapy among patients with major depressive disorder停用抗抑郁治疗的重度抑郁症患者

Open Journal of Psychiatry, 2012, 2, 272-280 OJPsych /10.4236/ojpsych.2012.24038 Published Online October 2012 (http://www.SciRP.org/journal/ojpsych/) Discontinuation of antidepressant therapy among patients with major depressive disorder 1* 2 2 1 2,3 Shreya Davé , Peter Classi , Trong Kim Le , Andrew Maguire , Susan Ball 1Epidemiology and Database Analytics, United BioSource Corporation, London, UK 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, USA 3Indiana University School of Medicine, Indianapolis, USA * Email: shreya.dave@ Received 27 June 2012; revised 29 July 2012; accepted 9 August 2012 ABSTRACT Keywords: Anti-Depressive Medications; Serotonin Uptake Inhibitors; Major Depressive Disorder; Objective: Patients with major depressive disorder Medication Adherence; General Practice (MDD) often discontinue antidepressant therapy pre- maturely risking relapse, despite United Kingdom (UK) guidelines recommending therapy for up to at 1. INTRODUCTION least six months after remission. More information is Approximately 13% of general practice attendees in the needed on the patterns of antidepressant discontinua- United Kingdom (UK) suffer major depressive disorder tion in UK primary care. Objectives of the study were (MDD) [1]