dna binding and antitumor activity of α-diimineplatinum(ii) and palladium(ii) dithiocarbamate complexesdna结合和抗肿瘤的活性α-diimineplatinum(ii)和钯(ii)二硫代氨基甲酸配合物.pdfVIP

Hindawi Publishing Corporation Bioinorganic Chemistry and Applications Volume 2011, Article ID 394506, 11 pages doi:10.1155/2011/394506 Research Article DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes Hassan Mansouri-Torshizi,1 Maryam Saeidifar,2 Fatemeh Khosravi,1 Adeleh Divsalar,3 Ali Akbar Saboury,4 and Fatemeh Hassani1 1 Department of Chemistry, University of Sistan and Baluchestan, Zahedan 98167-45345, Iran 2 Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj 31787-316, Iran 3 Department of Biological Sciences, Tarbiat Moallem University, Tehran 13145-1384, Iran 4 Institute of Biochemistry and Biophysics, University of Tehran, Tehran 13145-1384, Iran Correspondence should be addressed to Hassan Mansouri-Torshizi, hmtorshizi@ Received 23 May 2011; Accepted 25 July 2011 Academic Editor: Giovanni Natile Copyright © 2011 Hassan Mansouri-Torshizi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO3 (Oct-dtc = Octyldithiocarbamate and bpy = 2,2 -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO , have been synthesized and characterized by elemental 3 analyses, molar conductivity measurements, IR, 1H NMR, and electronic spectra studies. Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out. They show Ic50 values lower than that of cis