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dna-repair ercc1 gene polymorphisms in epithelial ovarian cancer and relation to platinum resistance and survivaldna修复ercc1基因多态性在卵巢癌上皮和铂电阻和生存
Journal of Cancer Therapy, 2011, 2, 140-147
doi:10.4236/jct.2011.22016 Published Online June 2011 (http://www.SciRP.org/journal/jct)
DNA-Repair ERCC1 Gene Polymorphisms in
Epithelial Ovarian Cancer and Relation to
Platinum Resistance and Survival
1,2 3 1,2
Karina Dahl Steffensen , Marianne Waldstrøm , Anders Jakobsen
1Department of Oncology, Vejle Hospital, Vejle, Denmark; 2Institute of Regional Health Services Research, University of Southern
Denmark, Odense C, Denmark; 3Pathology, Vejle Hospital, Vejle, Denmark.
Email: Karina.Dahl.Steffensen@slb.regionsyddanmark.dk
Received March 3rd, 2011; revised April 20th, 2011; accepted April 30th, 2011.
ABSTRACT
Objectives: Excision repair cross-complementation group 1 (ERCC 1) is a key DNA repair gene in the nucleotide exci-
sion repair pathway which is activated in the repair of intra- and interstrand DNA crosslink caused by platinum-based
treatment. Two single nucleotide polymorphisms (SNPs) of the ERCC 1 gene, codon 118 C/T and C8092A , have been
reported to be functional, but the influence on platinum resistance and survival is not yet clear. The primary aim of the
present study was to investigate whether the two SNPs were associated with resistance to standard combination car-
boplatin and paclitaxel chemotherapy and the potential prognostic impact in newly diagnosed ovarian cancer patients.
Methods : Serum samples from 202 patients with newly diagnosed ovarian cancer were assessed for ERCC 1 SNP geno-
typing using real time PCR. All patients were treated with first line carboplatin/paclitaxel chemotherapy. Results :
There were no correlation between the ERCC1 118 C/T and C8092A genotypes and platinum resistance (P = 0.79 and
P = 0.36, respectively). Furthermore, the results showed no association to progression free survival (P = 0.18 and P =
0.16, respectively) or o
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