downregulation of transforming growth factor-β (tgf-β) and vascular endothelial growth factor (vegf) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (sa-cmc)英文论文.pdfVIP

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downregulation of transforming growth factor-β (tgf-β) and vascular endothelial growth factor (vegf) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (sa-cmc)英文论文.pdf

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downregulation of transforming growth factor-β (tgf-β) and vascular endothelial growth factor (vegf) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (sa-cmc)英文论文

Vol.4, No.11, 808-818 (2012) Natural Science /10.4236/ns.2012.411108 Downregulation of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan * (SA-CMC) 1# 2 1 Salem A. Habib , Yassin A. Aggour , Hossam A. Taha 1Biochemistry Division, Chemistry Department, Damietta Faculty of Science, Mansoura University, Mansoura, Egypt; #Corresponding Author: Salem_habib@ 2Chemistry Departments, Damietta Faculty of Science, Mansoura University, Mansoura, Egypt Received 26 August 2012; revised 28 September 2012; accepted 10 October 2012 ABSTRACT regulation of TGF-β and VEGF. The present study was conducted to investigate Keywords: Transforming Growth Factor-β; the use of stearic acid-grafted carboxymethyl Vascular Endothelial Growth Factor; EAC Cells; chitosan (SA-CMC) as a downregulator for trans- Stearic Acid-Grafted Carboxymethyl Chitosan forming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) in Ehrlich as- cites carcinoma (EAC)-bearing mice. The anti- 1. INTRODUCTION tumor effect of stearic acid-grafted carboxyme- Many studies have demonstrated the role of reactive thyl chitosan was assessed by the estimation of oxygen species (ROS) in tumor development [1]. ROS TGF-β and VEGF in serum in addition to the es-