dna damage levels in systemic lupus erythematosus patients with low disease activity an evaluation by comet assay系统性红斑狼疮患者的dna损伤程度较低的疾病活动由彗星试验评估.pdfVIP

Advances in Bioscience and Biotechnology, 2012, 3, 983-988 ABB /10.4236/abb.2012.327121 Published Online November 2012 (http://www.SciRP.org/journal/abb/) DNA damage levels in systemic lupus erythematosus patients with low disease activity: An evaluation by comet assay 1,2 3 2 2 Thaís Muniz Montalvão , Ana Luisa Miranda-Vilela , Mariana Matos Roll , Cesar Koppe Grisolia , Leopoldo Santos-Neto1,4 1University Hospital of Brasília, University of Brasília, Brasília, Brazil 2Laboratory of Genetic Toxicology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil 3Department of Genetics and Morphology, Laboratory of Genetics, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil 4Faculty of Medicine, University of Brasilia, Brasília, Brazil Email: thaismunizms@ Received 1 August 2012; revised 12 September 2012; accepted 17 October 2012 ABSTRACT 1. INTRODUCTION Oxidative stress has been implicated in the inflam- Systemic Lupus Erythematosus (SLE) is a chronic matory process of Systemic Lupus Erythematosus autoimmune disease that predominantly affects women (SLE), particularly by the formation of anti-DNA of reproductive age [1,2]. It is caused by the interaction autoantibodies, which can lead to DNA damage. The of genetic, hormonal and environmental factors leading aim of this study was to investigate, through comet to dysfunction of T-cells, B-cells, and dendritic cells with assay, whether the level of DNA damage in SLE pa- the production of ant