effect of impaired lung function on the development and progression of endobronchial premalignant lesions肺功能受损的影响支气管病变恶化前的开发和发展.pdfVIP

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effect of impaired lung function on the development and progression of endobronchial premalignant lesions肺功能受损的影响支气管病变恶化前的开发和发展.pdf

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effect of impaired lung function on the development and progression of endobronchial premalignant lesions肺功能受损的影响支气管病变恶化前的开发和发展

Journal of Cancer Therapy, 2012, 3, 364-371 /10.4236/jct.2012.324048 Published Online September 2012 (http://www.SciRP.org/journal/jct) Effect of Impaired Lung Function on the Development and Progression of Endobronchial Premalignant Lesions 1,2,3 4 3,5 5 Vijayvel Jayaprakash , Gregory M. Loewen , Martin C. Mahoney , Samjot Dhillon , Sai Yendamuri6 7 8 9 , D. Kyle Hogarth , Enrique Machare-Delgado , Ravi J. Menezes , Sandra M. Jacob5, Mary E. Reid1,3,5* 1Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, USA; 2Department of Dentistry, Roswell Park Cancer Institute, Buffalo, USA; 3Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, USA; 4Pulmonary Oncology, Sacred Heart Medical Center, Spokane, USA; 5Department of Medicine, Roswell Park Cancer Institute, Buffalo, USA; 6Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, USA; 7Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, USA; 8School of Medicine, State University of New York at Buffalo, Buffalo, USA; 9Department of Medical Imaging, University Health Network, Toronto, Canada. * Email: mary.reid@ Received July 27th, 2012; revised August 29th, 2012; accepted September 11th, 2012 ABSTRACT Background: Chronic obstructive pulmonary disease (COPD) and the presence of endobronchial premalignant lesions (EPL) are individual risk factors for lung cancer (LC). However, effect of impaired lung function (ILF) on the natural history of EPL has not been explored. Patients and Methods: This study included 217 high-risk participants from a hospital-based LC surveillance cohort who underwent pulmonary function testin