effect of intervention in subjects with high risk of diabetes mellitus in pakistan干预的影响在巴基斯坦高糖尿病的风险.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2012, Article ID 867604, 7 pages doi:10.1155/2012/867604 Research Article Effect of Intervention in Subjects with High Risk of Diabetes Mellitus in Pakistan Muhammad Zafar Iqbal Hydrie,1, 2 Abdul Basit,2 A. Samad Shera,3 and Akhtar Hussain1 1 Section of International Community Health, Department of Community Medicine, Institute of Health and Society, Faculty of Medicine, University of Oslo, P.O. Box 1130, Blindern, Oslo, Norway 2 Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Block 2, Nazimabad, Karachi 74600, Pakistan 3 WHO Collaborating Centre, Diabetic Association of Pakistan, 5-E/3, Nazimabad, Karachi 74600, Pakistan Correspondence should be addressed to Muhammad Zafar Iqbal Hydrie, research@ Received 25 January 2012; Accepted 5 June 2012 Academic Editor: Bjørgulf Claussen Copyright © 2012 Muhammad Zafar Iqbal Hydrie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aims . To observe the rate of conversion from impaired glucose tolerance (IGT) to diabetes following lifestyle modification (LSM) or a combination of lifestyle and metformin compared to a control population with 18-month followup. Methods. Forty screening camps were organized, which 5000 people attended. Around 2300 persons filled the questionnaire and 1825 subjects were identified as high risk. Of 1739 subjects who took the oral glucose tolerance test, 317 subjects were identified as IGT. The 317 IGT subjects were randomized into three groups: control group was given standard medi