effect of magnesium on the mechanical and bioactive properties of biphasic calcium phosphate镁对机械和生物活性的影响双相磷酸钙的属性.pdfVIP

Journal of Minerals and Materials Characterization and Engineering, 2012, 11, 982-988 Published Online October 2012 (http://www.SciRP.org/journal/jmmce) Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate Ponnusamy Kanchana, Chinnathambi Sekar Department of Bioelectronics and Biosensors, Alagappa University, Karaikudi, India Email: Sekar2025@ Received August 12, 2012; revised September 15, 2012; accepted September 25, 2012 ABSTRACT Incorporation of trace elements into calcium phosphate structure is of great interest for the development of artificial bone implants. Biphasic calcium phosphate (BCP) composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) have been synthesized in the presence of magnesium (5 M% - 20 M%) by gel method under physiological conditions. Crystallization of Mg-BCP in the gel medium mimics the Mg intake in the human body. Powder X-ray dif- fraction and Fourier transform infrared analyses confirmed that the Mg doping leads to the enrichment of β-TCP phase and suppresses the HA content in BCP. Nanoindentation studies indicate a significant decrease in hardness and elastic modulus values of BCP due to Mg doping. In vitro bioactivity study has confirmed the formation of apatite layer on the Mg doped samples making it suitable for bone replacement. The results suggest that the optimum Mg doping promotes the bioactivity which is perquisite for biomedical applications. Keywords: Biphasic Calcium Phosphate; Crystal Growth; X-Ray Diffraction; Mechanical Properties 1. Introduction showed that the MgO-doped HA/β-TCP synthesized by convention