early and visible improvements after application of k101 in the appearance of nails discoloured and deformed by onychomycosis早,可见改进后应用k101指甲变色和变形的甲真菌病.pdfVIP

Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 59-63 doi:10.4236/jcdsa.2011.13010 Published Online September 2011 (http://www.SciRP.org/journal/jcdsa) Early and Visible Improvements after Application of K101 in the Appearance of Nails Discoloured and Deformed by Onychomycosis 1 2 3 Jan Faergemann , Sören Gullstrand , Kjell Rensfeldt 1Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden; 2Möllevångens Husläkargrupp, Malmö, Swe- den; 3Moberg Derma AB, Bromma, Sweden. Email: jan.faergemann@derm.gu.se Received June 9th, 2011; revised July 14th, 2011; accepted July 19th, 2011. ABSTRACT Onychomycosis is a fungal infection of the nails of the fingers and toes and is difficult to cure. A previous 24-week, placebo-controlled study demonstrated that a solution containing propylene glycol , urea and lactic acid (K 101) was well-tolerated and effective in the treatment of onychomycosis. Patients who received K101 judged that their condition had improved from Week 2 of treatment onwards. The aim of the current study was to further evaluate and document early visible effects on nail appearance after application of topical K 101 in an 8-week baseline-controlled study in 75 patients. Patients graded the appearance of their nail compared with baseline using a four-point scale. Compared with baseline, 91.8% (67/73; 95% confidence interval (CI): 83.0%, 96.9%) of the patients experienced at least some im- provement in their target nail after 8 weeks of treatment. At Week 2, the proportion showing some improvement was 76.7% (56/73; 95% CI: 65.4%, 85.8%) with this number increasing to 87.7% (64/73; 95% CI: 77.9%, 94.2%) at Week 4. Proportions of patients reporting less thickened, less discoloured, less brittle and softer nails increased over the course of the study. No safety issues were identified. In conclusion, K 101