early diagnosis of cardiac toxicity related to antineoplastic treatment早期诊断心脏毒性与抗肿瘤的治疗.pdfVIP

Journal of Cancer Therapy, 2011, 2, 161-166 161 doi:10.4236/jct.2011.22019 Published Online June 2011 (http://www.SciRP.org/journal/jct) Early Diagnosis of Cardiac Toxicity Related to Antineoplastic Treatment 1 2 3 4 Maria Maiello , Rakesh K. Sharma , Marco Matteo Ciccone , Humananth K. Reddy , Pasquale Palmiero5* 1Cardiology Department, ASL BR, Brindisi, Italy; 2Cardiology Chair, University of Arkansas for Medical Sciences, El Dorado, USA; 3Cardiology Chair, University of Bari, Bari, Italy; 4Clinical Professor of Medicine, University of St. Louis, Associate Medical Director Medical Center of South Arkansas St. Louis, Arkansas, USA; 5Contract Professor of Cardiology, University of Heart Station, Brindisi, Italy. Email: pasquale.palmiero@yahoo.it th rd st Received April 13 , 2011; revised May 23 , 2011; accepted May 31 , 2011. ABSTRACT Background : breast cancer because of radiotherapy and/or chemotherapy causes cardiac disease, often it occurs on women just affected by hypertension and/or diabetes. All these conditions may affect left ventricular (LV) geometry, mass and diastolic function. The purpose of this study is to early detect these affections to improve heart failure preven- tion. Patients and methods : 134 women, affected by breast cancer, underwent to conventional transthoracic echocar- diography (TTE) and pulse wave tissue Doppler imaging (PW-TDI). A control group (CG) of 80 women unaffected by breast cancer, hypertension and diabetes was enrolled. Results : 54 of 134 women (40.2%), were affected by hyperten- sion or diabetes too (Prone Group = PG), 8 by both, 80 (59.8%) were free (FG). Mean age of all patients was 45.4 years. The rates of LV eccen