early infant diagnosis (eid) of hiv an experience at a tertiary care hospital in india婴儿早期诊断(宰牲节)hiv病毒的一个经验对一所大学三级医院在印度.pdfVIP

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early infant diagnosis (eid) of hiv an experience at a tertiary care hospital in india婴儿早期诊断(宰牲节)hiv病毒的一个经验对一所大学三级医院在印度.pdf

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early infant diagnosis (eid) of hiv an experience at a tertiary care hospital in india婴儿早期诊断(宰牲节)hiv病毒的一个经验对一所大学三级医院在印度

World Journal of AIDS, 2012, 2, 1-5 1 /10.4236/wja.2012.21001 Published Online March 2012 (http://www.SciRP.org/journal/wja) Early Infant Diagnosis (EID) of HIV: An Experience at a Tertiary Care Hospital in India Supriya M. Paranjpe, Rajkunwar S. Phakade, Nayana A. Ingole, Preeti R. Mehta Department of Microbiology, Seth GS Medical College KEM Hospital, Mumbai, India. Email: supriyaparanjpe@ Received November 23rd, 2011; revised December 25th, 2011; accepted January 10th, 2012 ABSTRACT Introduction: Early infant diagnosis (EID) confers substantial benefit to HIV infected and HIV uninfected infants and to programmes providing prevention of mother to child transmission (MTCT), but has been challenging to implement in resource limited settings. Objectives: To find out the rate of perinatal transmission in infants born to HIV positive mothers, to study the effect of various predisposing factors on HIV transmission and to evaluate the utility of dried blood spot (DBS) specimen for EID of HIV. Methods: Infants born to HIV positive mothers were tested according to National AIDS Control Organization (NACO) guidelines. Infants of 6 weeks to 6 months of age (n = 84) were diag- nosed by DBS PCR; DBS positive results were confirmed by whole blood PCR. Infants 6 - 18 months (n = 47) were subjected to antibody test and if positive were confirmed by DNA PCR. Detailed history including type of delivery, single dose nevirapine (SDN) and breast feeding was taken. Results: The HIV transmission rate was 10.69%. In chil- dren ≤ 6 months, who did not receive SDN the positivity was 44.44% (4/9) whereas in those who received SDN it was 6.66% (5/75), (P = 0.0063). In children 6 months the positivity rate was significantly higher in breast fed 42.85% (3/7) as compared to non breast fed 5% (2/40) children (P = 0.0187