early onset multiple sclerosis has worse prognosis than adult onset multiple sclerosis based on cognition and magnetic resonance imaging早发性多发性硬化症有预后比成人发病多发性硬化症基于认知和磁共振成像.pdfVIP

Hindawi Publishing Corporation Autoimmune Diseases Volume 2012, Article ID 563989, 5 pages doi:10.1155/2012/563989 Clinical Study Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging Serkan Ozakbas, Derya Kaya, and Egemen Idiman ˙ Department of Neurology, Dokuz Eylul University, Balc¸ova, 35340 Izmir, Turkey ¨ Correspondence should be addressed to Serkan Ozakbas, serkan.ozakbas@.tr Received 14 July 2012; Accepted 16 October 2012 Academic Editor: Ricard Cervera Copyright © 2012 Serkan Ozakbas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. In the present study, we aimed to compare the childhood and adult onset multiple sclerosis patients prospectively in their adulthood on the basis of clinical and magnetic resonance imaging (MRI) findings and cognitive impairment, which have not been performed before. Patients and Methods. Forty-six patients in whom the disease onset occurred before 16 years of age were included in the present study. Study subjects were compared with 64 randomly included adult onset patients. Results. Mean disease duration, clinical course, and female to male ratio did not differ in the groups. Cerebellar/brainstem and spinal involvement at onset were significantly higher in EOMS than in AOMS. Difference in MSFC between baseline and at the end of the 5th year was significantly worse in EOMS population (P = 0.02). The most significant difference was found in Paced