dyscirculatory angiopathy of alzheimers type阿尔茨海默氏症类型的dyscirculatory血管病.pdfVIP

Journal of Behavioral and Brain Science, 2011, 1, 57-68 doi:10.4236/jbbs.2011.12008 Published Online May 2011 (/journal/jbbs) Dyscirculatory Angiopathy of Alzheimer’s Type Ivan V. Maksimovich Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Russia E-mail : carvasc@yandex.ru Received March 15, 2011; revised March 30, 2011; accepted April 2, 2011 Abstract Purpose : We assess the significance of dyscirculatory angiopathy of Alzheimer’s type (DAAT) in identify- ing the predisposition to the development and diagnosis of Alzheimer’s disease (AD) different stages. Meth- ods: 108 patients took part in the research:1) 49 aged 34-79 suffering from AD or running an increased risk of its development (those not diagnosed with AD but having growing memory disorders without any mani- festations of dementia or specific cognitive impairments, and having 2 or more immediate relatives with AD) - Test Group; 2) 59 aged 28-78 suffering from different types of brain lesions accompanied by dementia but not suffering from AD or corresponding to their age norm - Control Group. All the patients underwent MRI, CT with subsequent calculation of the temporal lobes atrophy degree, brain scintigraphy (SG), rheoencepha- lography (REG), and MUGA. Results : Characteristic features of patients with an increased risk of AD as well as at its various stages are: 1) Temporal lobes and hippocampus atrophy ranging from 4% among those with an increased risk of AD to 62% among those at its advanced stages; 2) DAAT manifestations: reduction of the capillary bed in the temporal and frontoparietal regions with the development of multiple arterioven- ous shunts of the same localization and correspondent early venous discharge accompanied by venous stasis on the border of the frontal and parietal region; 3