effects of dietary and physical activity intervention during pregnancy on circulating leptin and adiponectin levels怀孕期间的饮食和身体活动干预对循环瘦素和脂联素水平.pdfVIP

Food and Nutrition Sciences, 2012, 3, 556-567 /10.4236/fns.2012.34078 Published Online April 2012 (http://www.SciRP.org/journal/fns) Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels 1 1 2,3 2,4* Leena Hilakivi-Clarke , Sonia de Assis , Jani Raitanen , Riitta Luoto 1Lombardi Cancer Center, Georgetown University, Washington DC, USA; 2UKK Institute for Health Promotion, Tampere, Finland; 3 4 School of Health Sciences, University of Tampere, Tampere, Finland; National Institute for Health and Welfare, Helsinki, Finland. * Email: riitta.luoto@uta.fi Received January 10th, 2012; revised March 8th, 2012; accepted March 16th, 2012 ABSTRACT Objective: We investigated whether lifestyle intervention during pregnancy modifies pregnancy leptin and adiponectin levels, adipokines and their association with body mass index (BMI). Methods: Of the 126 pregnant nulliparous women recruited, 43 in the intervention and 56 in the control group completed the study. Blood samples were collected on gestation weeks 8 - 10 (baseline) and weeks 36 - 38 (end of the intervention). Statistical analyses included group-based correlations between adipokines, pre-pregnancy BMI and gestational weight gain and covariance analysis including all confounding factors. Results: Pre-pregnancy BMI correlated with baseline (p = 0.023 and p = 0.079) and end leptin levels (p = 0.128 and p 0.001). Similarly, gestational weight gain correlated with both baseline (p = 0.009 and p = 0.046) and end leptin levels (p = 0.065 and p = 0.011). BMI at the end of pregnancy correlated with the end leptin levels, but the correlation was weaker in the control (p = 0.043) th