effects of dietary protein and fat contents on renal function and inflammatory cytokines in rats with adriamycin-induced nephrotic syndrome膳食中的蛋白质和脂肪含量对肾功能的影响和炎性细胞因子在大鼠adriamycin-induced肾病综合症.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2011, Article ID 945123, 9 pages doi:10.1155/2011/945123 Research Article Effects of Dietary Protein and Fat Contents on Renal Function and Inflammatory Cytokines in Rats with Adriamycin-Induced Nephrotic Syndrome Su Yeon Kim,1 A Young Lim,1 Su Kyung Jeon,1 In Seok Lee,1 and Ryowon Choue1, 2 1 Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Seocheon-dong, Giheung-gu, Yongin, Gyeonggi-do 446-701, Republic of Korea 2 Research Institute of Medical Nutrition, Kyung Hee University, Heikidong, Seoul 130-701, Republic of Korea Correspondence should be addressed to Ryowon Choue, rwcho@khu.ac.kr Received 9 October 2010; Accepted 3 March 2011 Academic Editor: Alex Kleinjan Copyright © 2011 Su Yeon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The effects of dietary protein and fat on renal function-related blood and urine parameters, such as albumin, urinary protein,and inflammatory cytokines were investigated in adriamycin- (ADR) induced nephrotic syndrome rats. ADR (2 mg/kg BW) was injected i.p. weekly for six weeks to develop nephrotic syndrome; thereafter rats were fed low-protein/high-fat (LPHF) or high- protein/low-fat (HPLF) diets for five weeks. Renal function-related blood and urine parameters were measured before and after dietary intervention. Serum levels of albumin, TG, and creatinine were significantly higher in the LPHF group than in the HPLF group. Serum levels of albumin were low and urinary protein excretion protein was high in HPLF group. BUN and UUN levels were