补肾健脾方对去卵巢大鼠脑组织中单胺类神经递质含量影响.docVIP

补肾健脾方对去卵巢大鼠脑组织中单胺类神经递质含量影响摘 要：目的：补肾健脾中药治疗妇女围绝经期综合征的临床疗效。方法：治疗组采用自拟补肾健脾口服方，并与更年康相对照，观察治疗前后妇女围绝经期综合征的症状评分，同时放免测定了部分患者治疗前后血清性激素的含量。结果：(1)补肾健脾中药能明显改善围绝经期综合征患者各主要症状，痊愈率为28.57%，总有效率达91.42%，较更年康疗效显著(P0.05)；缓解胸闷心悸、烦燥易怒、倦怠乏力、浮肿症状显著优于更年康对照组(P0.05或P0.01)。(2)补肾健脾中药能明显升高50岁以下患者E2水平(P0.05)。结论：补肾健脾法治疗妇女围绝经期综合征的疗效可靠，并对尚未完全衰退的卵巢功能有促进和调节作用。 关键词：去卵巢大鼠；下丘脑神经递质；补肾健脾方 中图分类号：R-33 文献标识码：A 文章编号：1673-7717(2008)03-0632-02 The Effects of the Invigorating the Kidney and the Spleen Prescription to the Content of Mono-amines Neurotransmitter in the Brain Tissues of De-ovary Rat FAN Hong-xia，LIN Qiong-xia (Affiliated Shenzhen Hospital to Guangzhou University of Chinese Medicine，Shenzhen 518033，Guangdong，China) Abstract：Objective：Investigate the mechanism of the invigorating the kidney and the spleen prescription to the regulatory function of autonomic nerve. Methods：This passage used de-ovary rat as animal model to simulate the diminishing ovary function during peri-menopusual period，and investigated The effects of the invigorating the kidney and the spleen prescription to the content of mono-amines neurotransmitter in brain tissues of de-ovary rat. Geng-nian-kang was used for comparison. Results：After removing ovary from rat，the respective automatic neurotransmitter in hypothalamus was affected. The ratio of 5-HT/NE increased significantly. The invigorating the kidney and the spleen prescription could effectively regulate the content of automatic neurotransmitter and resume it to another equilibrium state. The respective effect was greater than using Geng-nian-kang. Conclusion：The invigorating the kidney and the spleen prescription could suppress the synthesis of 5-HT in de-ovary rat，promote the function of the noradrenaline neuron of de-ovary rat，regulate the animes automatic neurotransmitter，and resume it to another equilibrium state. Keywords：de-ovary rat；automatic neurotransmitter in hypothalamus；the invigorating the kidney and the spleen prescription 笔者运用补肾健脾