原创力文档efficacy and toxicity of metronomic capecitabine in advanced hepatocellular carcinoma月复一月的疗效和毒性卡培他滨在先进的肝细胞癌.pdfVIP
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efficacy and toxicity of metronomic capecitabine in advanced hepatocellular carcinoma月复一月的疗效和毒性卡培他滨在先进的肝细胞癌
Journal of Cancer Therapy, 2012, 3, 71-77 71
/10.4236/jct.2012.31010 Published Online February 2012 (http://www.SciRP.org/journal/jct)
Efficacy and Toxicity of Metronomic Capecitabine in
*
Advanced Hepatocellular Carcinoma
Ashraf Farrag
Clinical Oncology Department, Assiut University Hospital, Assiut, Egypt.
Email: darshraffarrag@
Received November 21st, 2011; revised December 20th, 2011; accepted January 5th, 2012
ABSTRACT
Background: Hepatocellular carcinoma (HCC) is a hypervascular tumor. Metronomic chemotherapy; the continuous
administration of low-dose chemotherapy; has both cytotoxic and antiangiogenic effects with low toxicity profile. We
evaluated the efficacy and toxicity of metronomic capecitabine (MC) in patients with advanced HCC. Patients and
Methods: From May 2010, we enrolled pts with either metastatic or locally advanced diseases not candidate for abla-
tive or locoregional treatment and have acceptable liver function. Patients received oral MC in dose of 1000 mg/m2
daily in a 21 days cycle without interruption till disease progression or toxicity. Results: The study cohort consisted of
22 patients with a median age of 63 years. The median number of cycles received was 3 cycles (range 1 - 9). From 19
patients were evaluable for response we had 3 partial responders, 10 stable diseases and disease progression in 6 pa-
tients. Median time to progression (TTP) was 2.2 months (95% CI 1.4 - 6.24) and median survival time (OS) was 4.8
months (95% CI 1.8 - 7.9). For 20 patients evaluable for safety: no grade III/IV hematological toxic effects were ob-
served. Non-hematological toxic effects included grade III vomiting and diarrhea in one patient and grade III hand-foot
syndrome in one patient. There was no
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