GP方案治疗晚期恶性胸膜间皮瘤17例近期疗效观察.pdfVIP

JOURNAL OF BASIC AND CLINICAL ONCOLOGY Vo1．2l No．1 Feb．2008 GP方案治疗晚期恶性胸膜间皮瘤17例近期疗效观察 陈冬梅，王建红 (南通市肿瘤医院内科，江苏 南通226361) 摘要：目的 评价健择(GEM)加顺铂(DDP)组成的GP方案治疗晚期恶性胸膜问皮瘤的近期疗效。方法 经病理证实且有化疗指 征的Ⅲ期或Ⅳ期恶性胸膜问皮瘤 l7例，采用 GP方案全身化疗，GEM l 000 mg／m 加入生理盐水 100 mL中静脉滴注30 min，d ； DDP 30 mg／m 加入生理盐水 500 mL中静脉滴注，d ；2l d重复疗程，均化疗 2疗程后评价疗效。结果 本方案的有效率为 41．18％，中位生存期为l3月，初治者的有效率略高于复治者，但经统计学处理两者差异无统计学意义(P0．05)。结论 GEM十 DDP联合方案治疗恶性胸膜问皮瘤有较好的临床疗效，值得临床推广应用。 关键词：恶性胸膜问皮瘤；健择；化疗 中图分类号：R730．53；R734．3 文献标识码：A 文章编号：l673—54l2(2008)0l一0050—02 Short—Term Curative Effect of GP Regimen on 1 7 Cases with Advanced Malignant Pleura1 Mesothelioma Chen Dongmei，Wang Jianhong (Nantong Tumor Ho~ital，Nantong 22636 1，China) Abstract：Objective To explore the efficacy and safety of GP regimen including gemcitabine(GEM)and cisplatin(DDP)as therapy for patients with advanced malignant pleural mesothelioma．Methods 17 patients of pathologically confirmed clinic stageⅢ．IV malignant pleural mesothelioma were treated at our hospita1．The 17 patients with advanced malignant pleural mesothelioma were administrated with in— travenous GEM 1 000 mg／m dispensed in 100 mL normal saline(NS)，i．v，30 min，d¨，and intravenous DDP 30 mg／m dispensed in 500 mL normal saline(NS)，i．v，30 min，d¨，one time，each 3 weeks．Results The 17 patients were assessable and the results indica— ted that total response rate was 41．18％．The median survival period was 13 months．The response rate of curative effect of GP regimen was higher in initial cases with advanced malignant pleural mesothelioma than that in the cases of repeated treatment．But there was no significant difference between the initial cases and the cases repeated treatment(P0．05)．Conclusions It is effective and safe for GP re