原创力文档a unique radiation scheme for the treatment of high-grade non-metastatic soft tissue sarcoma the detroit medical center experience一个独特的辐射方案高档non-metastatic软组织肉瘤的治疗底特律医疗中心的经验.pdfVIP
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a unique radiation scheme for the treatment of high-grade non-metastatic soft tissue sarcoma the detroit medical center experience一个独特的辐射方案高档non-metastatic软组织肉瘤的治疗底特律医疗中心的经验
Sarcoma, September/December 2005; 9(3/4): 141–145
ORIGINAL ARTICLE
A unique radiation scheme for the treatment of high-grade
non-metastatic soft tissue sarcoma: The Detroit
Medical Center experience
1 2 3
JAMES FONTANESI , MICHAEL P. MOTT , MICHAEL J. KRAUT ,
4 5
DAVID R. LUCAS , PETER R. MILLER
1Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39216,
2Department of Orthopedic Surgery, Wayne State University School of Medicine, Pathology and Diagnostic Imaging,
3Department of Medical Oncology, Providence Hospital, Barbara Ann Karmanos Cancer Institute,
4Department of Pathology, Wayne State University School of Medicine, and 5Department of Radiology,
Wayne State University School of Medicine, Detroit Medical Center, Wayne State University,
4100 John R, Detroit, MI 48201, USA
Abstract
Purpose: This is the initial report on the utilization of combined photon irradiation followed by a neutron boost irradiation
for the initial management of patients with high-grade non-metastatic soft tissue sarcoma (STS). We present data on local
control, complications, disease-free survival and overall survival in patients at high risk for local relapse.
Methods and materials: Between 1/1/1995 and 10/31/02, twenty-three patients with high-grade non-metastatic soft tissue
sarcoma were referred to the Department of Radiation Oncology at the Detroit Medical Center. These patients were
referred for consultation due to surgical margin status (tumor within 3 mm of surgical margin (n ¼ 11)), or gross residual
disease (n ¼ 12). There were 14 males and nine females whose ages ranged from 12 to 75 at the time of diagnosis (med ¼ 44
years). The most common histology was malignant fibrous histiocytoma (n ¼ 6), followed by liposarcoma (n
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