原创力文档altered polarization, morphology, and impaired innate immunity germane to resident peritoneal macrophages in mice with long-term type 2 diabetes改变极化、形态学和先天免疫受损与居民长期腹膜巨噬细胞在小鼠2型糖尿病.pdfVIP
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altered polarization, morphology, and impaired innate immunity germane to resident peritoneal macrophages in mice with long-term type 2 diabetes改变极化、形态学和先天免疫受损与居民长期腹膜巨噬细胞在小鼠2型糖尿病
Hindawi Publishing Corporation
Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 867023, 9 pages
doi:10.1155/2012/867023
Research Article
Altered Polarization, Morphology, and Impaired Innate
Immunity Germane to Resident Peritoneal Macrophages in
Mice with Long-Term Type 2 Diabetes
Hui-Fang Liu,1 Hui-Jie Zhang,1 Qi-Xian Hu,1 Xiao-Yan Liu,1
Zhi-Quan Wang,2 Jia-Yan Fan,3 Ming Zhan,2 and Feng-Ling Chen1
1 Department of Endocrinology, The Shanghai Third People’s Hospital, Shanghai Jiao Tong University School of Medicine,
280 Mohe Road, Shanghai 201900, China
2 State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,
197 Ruijin No. 2 Road, Shanghai 200025, China
3 Department of Ophthalmology, The Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine,
639 Zhizaoju Road, Shanghai 200011, China
Correspondence should be addressed to Feng-Ling Chen, fengling chen@
Received 17 March 2012; Revised 13 June 2012; Accepted 29 June 2012
Academic Editor: Soldano Ferrone
Copyright © 2012 Hui-Fang Liu et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type 2 diabetes (T2D) is associated with perturbed innate immunity. Macrophages, bridging innate immunity and metabolic
disturbances, play important roles in controlling immune homeostasis. However, the effect of long-term diabetic milieu (DM) on
the functions and phenotypes of macrophages is still not clear. In this study, we used resident peritoneal macrophages (RPMs) from
5-month-old db/db mice to investigate the changes of macrophages. It was found that RPMs in
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