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Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 343989, 5 pages doi:10.1155/2012/343989 Research Article Biocompatibility Evaluation of a New Hydrogel Dressing Based on Polyvinylpyrrolidone/Polyethylene Glycol Esmaeil Biazar,1 Ziba Roveimiab,2 Gholamreza Shahhosseini,3 Mohammadreza Khataminezhad,4 Mandana Zafari,5 and Ali Majdi5 1 Department of Chemistry, Tonekabon branch, Islamic Azad University, Tonekabon, Iran 2 Young Researchers Club, Science and Research Branch, Islamic Azad University, Tehran, Iran 3 Nuclear Agriculture Research Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Institute, Iran 4 Department of Microbiology, Tonekabon branch, Islamic Azad University, Tonekabon, Iran 5 Young Researchers Club, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran Correspondence should be addressed to Esmaeil Biazar, e.biazar@tonekaboniau.ac.ir Received 27 March 2011; Revised 22 June 2011; Accepted 23 June 2011 Academic Editor: Masa-Aki Shibata Copyright © 2012 Esmaeil Biazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The composition of the dressings is based on polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and agar. The electron beam irradiation technique has been used to prepare hydrogel wound dressings. The in vitro biocompatibility of the hydrogel was investigated by check samples (hydrocolloid Comfeel), antibacterial test (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia Coli k12), anti fungal test (Candida Albicans) and cytotoxic