原创力文档camp activates the generation of reactive oxygen species and inhibits the secretion of il-6 in peripheral blood mononuclear cells from type 2 diabetic patients营激活活性氧的生成,抑制il - 6的分泌在2型糖尿病患者外周血单核细胞.pdfVIP
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camp activates the generation of reactive oxygen species and inhibits the secretion of il-6 in peripheral blood mononuclear cells from type 2 diabetic patients营激活活性氧的生成,抑制il - 6的分泌在2型糖尿病患者外周血单核细胞
ReseaRCh papeR ReseaRCh papeR
Oxidative Medicine and Cellular Longevity 2:5, 317-321; November/December 2009; © 2009 Landes Bioscience
caMp activates the generation of reactive oxygen
species and inhibits the secretion of IL-6 in
peripheral blood mononuclear cells from type 2
diabetic patients
1 1 1 1 2
Camila armond Isoni, Érica abreu Borges, Clara araújo Veloso, Rafael Teixeira Mattos, Miriam Martins Chaves
1,
and José augusto Nogueira-Machado *
1Núcleo de Pós-Graduação e Pesquisa; Hospital Santa Casa de Belo Horizonte; Belo Horizonte; Minas Gerais, Brasil; 2 Departamento de Bioquímica e Imunologia;
Universidade Federal de Minas Gerais; Belo Horizonte; Minas Gerais, Brazil
Key words: ROS, IL-6, cAMP, diabetes, peripheral blood mononuclear cells
peripheral blood mononuclear cells (pBMNC) from patients with type 2 diabetes (DM2) have generated higher levels of
reactive oxygen species (ROs) that were higher than those in cells from healthy individuals. In the presence of a ca Mp-
elevating agent, ROS production was significantly activated in PBMNC from DM2 patients but it was inhibited in cells from
healthy subjects. higher levels of IL-6 has been detected in the supernatant of pBMNC cultures from DM2 patients in
comparison with healthy controls. When cells were cultured in the presence of a ca Mp-eleva
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