role of kit-positive interstitial cells of cajal in the urinary bladder and possible therapeutic target for overactive bladder的角色kit-positive卡哈尔间质细胞的膀胱膀胱过动症和可能的治疗目标.pdf

Hindawi Publishing Corporation Advances in Urology Volume 2011, Article ID 816342, 7 pages doi:10.1155/2011/816342 Review Article Role of KIT-Positive Interstitial Cells of Cajal in the Urinary Bladder and Possible Therapeutic Target for Overactive Bladder Yasue Kubota, Yoshiyuki Kojima, Yasuhiro Shibata, Makoto Imura, Shoichi Sasaki, and Kenjiro Kohri Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan Correspondence should be addressed to Yasue Kubota, yasuekbt@med.nagoya-cu.ac.jp Received 31 January 2011; Revised 4 April 2011; Accepted 5 June 2011 Academic Editor: John PFA Heesakkers Copyright © 2011 Yasue Kubota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the gastrointestinal tract, interstitial cells of Cajal (ICCs) act as pacemaker cells to generate slow wave activity. Interstitial cells that resemble ICCs in the gastrointestinal tract have been identified by their morphological characteristics in the bladder. KIT is used as an identification marker of ICCs. ICCs in the bladder may be involved in signal transmission between smooth muscle bundles, from efferent nerves to smooth muscles, and from the urothelium to afferent nerves. Recent research has suggested that not only the disturbance of spontaneous contractility caused by altered detrusor ICC signal transduction between nerves and smooth muscle cells but also the disturbance of signal transduction between urothelial cells and sensory nerves via suburothelial ICC may induce overactive bladder (OAB). Recent reports have suggested that KIT is not only a detection marker of these cells,