scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease清道夫受体和潜在的治疗靶点治疗心血管疾病.pdf

SAGE-Hindawi Access to Research International Journal of Hypertension Volume 2010, Article ID 646929, 21 pages doi:10.4061/2010/646929 Review Article Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease Sam L. Stephen,1 Katie Freestone,1 Sarah Dunn,1 Michael W. Twigg,1, 2 Shervanthi Homer-Vanniasinkam,1, 2 John H. Walker,1 Stephen B. Wheatcroft,3 and Sreenivasan Ponnambalam1 1 Endothelial Cell Biology Unit, Institute of Molecular Cellular Biology, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK 2 Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK 3 Academic Unit of Molecular and Vascular Medicine, Faculty of Medicine and Health, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK Correspondence should be addressed to Sreenivasan Ponnambalam, s.ponnambalam@leeds.ac.uk Received 6 May 2010; Accepted 7 July 2010 Academic Editor: Stephen B. Harrap Copyright © 2010 Sam L. Stephen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of atherosclerotic plaques. In vascular tissues, scavenger receptors are implicated in regulating intracellular signaling, lipid accumulation, foam cell development, and cellular apoptosis or necrosis linked to the pathophysiology of atherosclerosis. On