serum il-1, il-6, il-8, and tnf- levels in early diagnosis and management of neonatal sepsis引发,血清il - 1、il - 6和tnf水平新生儿脓毒症的早期诊断和管理.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2007, Article ID 31397, 5 pages doi:10.1155/2007/31397 Research Article Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis A. Nese Citak Kurt,1 A. Denizmen Aygun,1 Ahmet Godekmerdan,2 Abdullah Kurt,1 Yasar Dogan,1 and Erdal Yilmaz1 1 Department of Pediatrics, Faculty of Medicine, Firat University, 23119 Elazig, Turkey 2 Department of Immunology, Faculty of Medicine, Firat University, 23119 Elazig, Turkey Correspondence should be addressed to A. Nese Citak Kurt, nkurt@fi.tr Received 10 May 2007; Accepted 31 October 2007 Aim . To determine serum IL-1β, IL-6, IL-8, and TNF-α levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n = 12), as culture-negative sepsis (n = 21), and as healthy newborns (n = 17). Results. At the time of diagnosis, serum IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis were significantly higher than those of the control groups (P .05). At the time of diagnosis, IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1β, IL-6, IL-8, and TNF-α are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis. Copyright © 2007 A. Nese Citak Kurt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided