six years follow-up of the levels of tnf- and il-6 in patients with complex regional pain syndrome type 16年随访的患者tnf和il - 6水平的复杂区域疼痛综合征1型.pdf
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six years follow-up of the levels of tnf- and il-6 in patients with complex regional pain syndrome type 16年随访的患者tnf和il - 6水平的复杂区域疼痛综合征1型
Hindawi Publishing Corporation
Mediators of Inflammation
Volume 2008, Article ID 469439, 7 pages
doi:10.1155/2008/469439
Research Article
Six Years Follow-up of the Levels of TNF-α and IL-6 in
Patients with Complex Regional Pain Syndrome Type 1
Feikje Wesseldijk,1 Frank J. P. M. Huygen,1 Claudia Heijmans-Antoissen,2
Sjoerd P. Niehof,2 and Freek J. Zijlstra2
1 Department of Anesthesiology, Pain Treatment Center, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
2 Department of Anesthesiology, Experimental Anesthesiology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
Correspondence should be addressed to Feikje Wesseldijk, f.wesseldijk@erasmusmc.nl
Received 11 February 2008; Accepted 6 May 2008
Recommended by Jan van Amsterdam
In an earlier study, levels of the proinflammatory cytokines TNF-α and IL-6 are higher in blisters fluid from the complex regional
pain syndrome type 1 (CRPS1) side obtained at 6 and 30 months (median) after the initial event. The aim of this follow-up study
is to determine the involvement of these cytokines in long lasting CRPS1. Twelve CRPS1 patients, with median disease duration of
72 months, participated. The levels of TNF-α and IL-6 were measured in blister fluid; disease activity was reevaluated by measuring
pain and differences in temperature, volume, and mobility between both extremities. Differences in levels of IL-6 and TNF-α and
mobility between both sides were significantly decreased. Pain and differences in temperature and volume were not significantly
altered. No correlation was found between the cytokines and the disease characteristics. These results indicate that IL-6 and TNF-α
are only partially responsible for the signs and symptoms of CRPS1.
Copyright © 2008 Feikje Wesseldijk et al. This is an open access
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