serum concentration of interleukin-6 is increased both in active and remission stages of pemphigus vulgaris血清白细胞介素- 6的浓度增加的活跃和缓解阶段寻常天疱疮.pdf

Hindawi Publishing Corporation Mediators of Inflammation Volume 2008, Article ID 875394, 5 pages doi:10.1155/2008/875394 Research Article Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris Joanna Narbutt,1 Jolanta Lukamowicz,2 Jarosław Bogaczewicz,1 Anna Sysa-Jedrzejowska,1 Jolanta Dorota Torzecka,3 and Aleksandra Lesiak1 1 Department of Dermatology, Medical University of Lodz, 94-017 Lodz, Poland 2 Laboratory of Immunochemical Research, Polish Mother’s Memorial Hospital Research Institute, 93-338 Lodz, Poland 3 Department of Immunodermatology, Medical University of Lodz, 94-017 Lodz, Poland Correspondence should be addressed to Joanna Narbutt, joanna.narbutt@onet.pl Received 24 January 2008; Accepted 11 May 2008 Recommended by Yona Keisari As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P .05). In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (rP = 0.46; P .05). We also found a negative correlation between TNF-α level and pemphigus antibodies titer in the patients from the remission group (rS = −0.47303; P .02). Our data suggest that IL-6 and TNF-α may be involved in maintaining immunological disturbances in remission stage of PV. Copyright © 2008 Joanna Narbutt et al. This is an open access article distribut