slice-to-volume nonrigid registration of histological sections to mr images of the human brainslice-to-volume非刚性的组织学部分登记先生人类大脑的图像.pdf

Hindawi Publishing Corporation Anatomy Research International Volume 2011, Article ID 287860, 17 pages doi:10.1155/2011/287860 Research Article Slice-to-Volume Nonrigid Registration of Histological Sections to MR Images of the Human Brain Sergey Osechinskiy1 and Frithjof Kruggel1 1 Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA Correspondence should be addressed to Sergey Osechinskiy, sosechin@ Received 15 June 2010; Revised 12 August 2010; Accepted 8 September 2010 Academic Editor: Feng C. Zhou Copyright © 2011 S. Osechinskiy and F. Kruggel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Registration of histological images to three-dimensional imaging modalities is an important step in quantitative analysis of brain structure, in architectonic mapping of the brain, and in investigation of the pathology of a brain disease. Reconstruction of histology volume from serial sections is a well-established procedure, but it does not address registration of individual slices from sparse sections, which is the aim of the slice-to-volume approach. This study presents a flexible framework for intensity-based slice- to-volume nonrigid registration algorithms with a geometric transformation deformation field parametrized by various classes of spline functions: thin-plate splines (TPS), Gaussian elastic body splines (GEBS), or cubic B-splines. Algorithms are applied to cross-modality registration of histological and magnetic resonance images of the human brain. Registration performance is evaluated across a range of optimization algorithms and int