small bowel tumors clinical presentation, prognosis, and outcome in 33 patients in a tertiary care center小肠肿瘤的临床表现、预后和33名患者的结果在一个三级保健中心.pdf

Hindawi Publishing Corporation Journal of Oncology Volume 2008, Article ID 212067, 5 pages doi:10.1155/2008/212067 Clinical Study Small Bowel Tumors: Clinical Presentation, Prognosis, and Outcome in 33 Patients in a Tertiary Care Center Mirna H. Farhat,1 Ali I. Shamseddine,1 and Kassem A. Barada2 1 Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut, Riad El-Solh, Beirut 1107 2020, Lebanon 2 Division of Gastroenterology, Department of Internal Medicine, American University of Beirut, Riad El-Solh, Beirut 1107 2020, Lebanon Correspondence should be addressed to Kassem A. Barada, kb02@.lb Received 20 June 2008; Accepted 14 October 2008 Recommended by Masatoshi Kudo Introduction. Small bowel cancers are rare. Accumulation of data regarding their clinical presentation, pathologic features, prognostic factors, treatment modalities, and outcome is difficult. Methods. This is a retrospective study of the medical records of 33 patients with small bowel cancers treated at the American University of Beirut-Medical Center over a 20-year period. Results. The study included 25 males (76%) and 8 females (24%). Median age at presentation was 56 years. Most common symptoms were abdominal pain (66.7%) and weight loss (57.6%). Thirteen patients presented with abdominal emergencies (39.3%). Lymphoma was the most common malignant tumor (36.4%), followed by adenocarcinoma (33.3%), leiomyosarcoma (15.2%), gastrointestinal stromal tumors (12.1%), and neuroendocrine tumors (3.0%). Tumors were located in the duodenum in 30% of patients, jejunum in 33%, and ileum in 36%. Resectability rate was 72.7% and curative R0 resection was achieved in 54.1% (13/24) of patients. 5-year survival of the 33 patients was 24.2%. Conclusion.