structural, thermal and enzymatic analysis of naturally occurring and d-amino acid substituted peptides结构、热分子和酶分析天然酸肽代替.pdf

Advances in Bioscience and Biotechnology, 2012, 3, 900-908 ABB /10.4236/abb.2012.37111 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Structural, thermal and enzymatic analysis of naturally occurring and D-amino acid substituted peptides * Punitha Velmurugan, Raghava Rao Jonnalagadda , Balachandran Unni Nair Council of Scientific and Industrial Research-Central Leather Research Institute, Chemical Laboratory, Chennai, India * Email: jrrao@clri.res.in Received 6 August 2012; revised 8 September 2012; accepted 15 October 2012 ABSTRACT For example, D-Serine (D-Ser) plays an important role in neuroplasticity, memory [2,3] and learning, D-aspartic Designing of new peptide materials for biomedical acid (D-Asp) is involved in endocrine functions [4]. and protein engineering applications are important. D-AAs are associated with neurotransmission, hormonal In the present work an attempt has been made to synthesis in mammals and protection from proteolysis in study the effect of D-Leu in collagen like tetra peptide bacteria [5]. In case of mammals, D-AAs appear as pro- on the structure and stability of peptide against en- ducts of the vital activities of endogenous flora or during zymes and results are compared with its chiral coun-