a comparative survey of the frequency and distribution of polymorphism in the genome of xenopus tropicalis比较的调查的频率和分布在非洲爪蟾蜍的基因组多态性tropicalis.pdfVIP

A Comparative Survey of the Frequency and Distribution of Polymorphism in the Genome of Xenopus tropicalis 1,2 5 5 2,3 Chris Showell *, Samantha Carruthers , Amanda Hall , Fernando Pardo-Manuel de Villena , Derek Stemple5, Frank L. Conlon1,2,4 1 UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 2 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 3 Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 4 Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 5 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom Abstract Naturally occurring DNA sequence variation within a species underlies evolutionary adaptation and can give rise to phenotypic changes that provide novel insight into biological questions. This variation exists in laboratory populations just as in wild populations and, in addition to being a source of useful alleles for genetic studies, can impact efforts to identify induced mutations in sequence-based genetic screens. The Western clawed frog Xenopus tropicalis (X. tropicalis) has been adopted as a model system for studying the genetic control of embryonic development and a variety of other areas of research. Its diploid genome has been extensively sequenced and efforts are underway to isolate mutants by phenotype- and genotype-based approaches. Here, we describe a study of genetic polymorphism in laboratory strains of