原创力文档a mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis一个数学方法确定在gliomagenesis通路变化产生的时间顺序.pdfVIP
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a mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis一个数学方法确定在gliomagenesis通路变化产生的时间顺序
A Mathematical Methodology for Determining the
Temporal Order of Pathway Alterations Arising during
Gliomagenesis
1,2,3 4 5 5 2
Yu-Kang Cheng , Rameen Beroukhim , Ross L. Levine , Ingo K. Mellinghoff , Eric C. Holland ,
Franziska Michor1*
1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston,
Massachusetts, United States of America, 2 Cancer Biology and Genetics Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York,
United States of America, 3 Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, New York, United States of
America, 4 Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of
Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women’s Hospital, Brigham and Women’s
Hospital, Boston, Massachusetts, United States of America, and Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of
America, 5 Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Abstract
Human cancer is caused by the accumulation of genetic alterations in cells. Of special importance are changes that occur
early during malignant transformation because they may result in oncogene addiction and thus represent promising targets
for therapeutic intervention. We have previously described a computational approach, called Retracing the Evolutionary
Steps in Cancer (RESIC), to deter
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