左氧氟沙星治疗下呼吸道感染41例临床观察.docVIP

左氧氟沙星治疗下呼吸道感染41例临床观察[摘要] 目的:观察左氧氟沙星治疗下呼吸道感染的临床疗效及安全性。方法:选择下呼吸道感染患者41例,以左氧氟沙星0.2~0.3 g静滴,2次/d,连用7~14 d,平均用药时间9.6 d。结果:本组41例患者经治疗后,痊愈22例,显效15例,进步3例,无效1例,总有效率为90.24%。结论:左氧氟沙星是一种高效、安全的广谱抗生素,对下呼吸道感染有很好的治疗效果。 [关键词] 左氧氟沙星;下呼吸道感染;不良反应 [中图分类号] R714.253[文献标识码]A [文章编号]1673-7210(2009)07(a)-046-02 The clinical observation of Levofloxacin in the treatment of 41 cases of lower respiratory tract infection WANG Cunliang (Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) [Abstract] Objective: To observe the clinical efficacy and safety of Levofloxacin in the treatment of lower respiratory tract infection. Methods: 41 cases of patients with lower respiratory tract infection were selected, and treated with 0.2-0.3 g Levofloxacin by intravenous infusion, twice a day for 7-14 d, the average use time was 9.6 d. Results: After the treatment of 41 cases of patients in our study, 22 cases were fully recovered, 15 cases were effective, 3 cases were progressive, 1 case was ineffective, the total effective rate was 90.24%. Conclusion: Levofloxacin is an efficient and safe broad-spectrum antibiotics, and have a very good therapeutic effect on the lower respiratory tract infection. [Key words] Levofloxacin; Lower respiratory tract infection; Adverse reaction 左氧氟沙星是新型第3代氟喹诺酮类药物,为氧氟沙星光学活性S型异构体;具有抗菌谱广、抗菌作用强、组织分布广、生物利用度高等特点[1]。它的主要作用机制为抑制细菌DNA旋转酶活性,抑制细菌DNA的复制[2],对革兰阳性菌、革兰阴性细菌均有很强的作用,目前已广泛用于治疗多种细菌感染性疾病。我院2002年10月～2004年3月应用左氧氟沙星注射液治疗下呼吸道感染41例,效果良好,现报道如下: 1 资料与方法 1.1 一般资料 本组41例均为住院患者,其中,男26例,女15例;年龄39~84岁,平均61.4岁;60岁以上30例,占73.17%。均无喹诺酮类药物过敏史,无肝、肾功能损害,无妊娠哺乳期妇女,无神经及精神系统疾病史。41例中,慢性支气管炎急性发作27例,肺炎11例,支气管扩张合并感染2例,急性支气管炎1例。 1.2 诊断标准 ①有咳嗽、咳痰、发冷、发热、胸痛、咯血、气急等症状,或原有慢性呼吸道病史,近期症状发作或加重者;②听诊双肺或单侧肺呼吸音增粗或有干、湿性?音;③WBC10×109/L或 1