我院169例抗菌药物不良反应报告回顾性分析.docVIP

我院169例抗菌药物不良反应报告回顾性分析[摘要] 目的:了解我院近3年来抗菌药物不良反应(ADR)的发生和分布情况,为临床使用抗菌药物提供参考。方法:对我院2006～2008年临床科室上报的169例抗菌药物不良反应报告按抗菌药物种类、名称、给药途径、ADR临床表现等进行回顾性统计分析。结果:169例抗菌药物不良反应报告中涉及的抗菌药物9大类,46个品种;以静脉给药为主;主要不良反应为皮肤及附件损害、全身性损害、胃肠道损害等。结论:医疗机构必须加强抗菌药物不良反应监测,以减少或避免ADR的发生。 [关键词] 抗菌药物;不良反应;回顾性分析 [中图分类号] R969[文献标识码] C[文章编号] 1673-7210(2010)03(b)-122-02 A retrospective analysis of 169 cases of adverse drug reactions induced by antibacterials in our hospital XU Guohua, LI Qing, GE Hongxing (The People’s Hospital of Fengcheng City, Jiangxi Province, Fengcheng 331100, China) [Abstract] Objective: To study the occurrence and distribution of adverse drug reactions(ADR) reduced by antibacterials in our hospital in three years lately, and to provide reference to clinical rational drug use of antibacterial agents. Methods: 169 reports of ADR cases induced by antibacterials from 2006 to 2008 in our hospital clinical departments were collected and analyzed retrospectively by drug types, drug names, route of administration and clinical manifestations. Results: 46 drugs of9 categories were involved in 169 reports of ADR. Most of them resulted from intravenous medication. The main side effects were injuries of skin and its appendages and systemic damage and gastrointestinal damage, etc. Conclusion: To reduce or avoid the occurrence of ADR, the monitor of ADR on antibacterials should be strengthened and in medical institutions. [Key words] Antibacterial agent; Adverse drug reaction; Retrospective analysis 抗菌药物是目前临床使用广泛的一类药物,随着抗菌药物品种规格日益增多,临床使用抗菌药物引发的不良反应数量也随之上升。我院在2006～2008年收集的不良反应(adverse drug reactions,ADR)报告中,有169例为抗菌药物引发。为了解临床使用该类药物的ADR发生情况,分析ADR发生相关因素,现将所收集到的169例抗菌药物ADR报告进行回顾性分析,为临床规范使用抗菌药物提供参考。 1 资料与方法 资料来源于我院2006～2008年由全院临床科室上报的298例ADR报告表,其中涉及抗菌药物的ADR报告有169例,占56.71%。将169例抗菌药物ADR资料进行归集汇总,分别对报告所涉及的患者性别与年龄、引发ADR的抗菌药物种类、名称、给药途径、ADR的发生例数、临床表现等进行统计分析。 2 结果 2.1 ADR患者性别与年龄分布 169例ADR报告中,男性84例,占49.71%;女性85例,占50.29%;男性和女性比例相近。从年龄的统计数据来看患者年龄最小为2个月,最大为91岁。各年龄组发生情况见表1。2.2 引发