白藜芦醇外涂对模拟日光照射所致皮肤红斑抑制作用.docVIP

白藜芦醇外涂对模拟日光照射所致皮肤红斑抑制作用[摘要]目的：观察白藜芦醇外涂对模拟日光照射皮肤红斑的影响。方法：将20名志愿者左右侧背部分别划出6个部位。部位1～4分别涂抹白藜芦醇+抗氧化剂、抗氧化剂、白藜芦醇、基质，左侧先涂抹后照光，右侧先照光后涂抹；部位5、6分别为阳性及阴性对照。连续4天，观察皮肤红斑。结果：照光后第１、2天，部位1～3无或隐约可见淡红斑；第3、4天，部位1、3红斑较第2天无加深，部位2红斑加深但较部位5轻。左侧形成的红斑较右侧相应部位轻。结论：白藜芦醇外用可有效预防与治疗模拟日光照射诱导的皮肤红斑，尤以预防性应用效果更好。 [关键词]白藜芦醇；紫外线；红斑 [中图分类号]R758 [文献标识码]A [文章编号]1008-6455（2012）05-0754-03 Inhibitive effects of topical resveratrol on skin erythema induced by solar simulator ultraviolet irradiation WU Yan1,JIA Li-li2,ZHENG Ying-na3,GAO Xing-hua1,CHEN Hong-duo1,LI Yuan-hong1 (1.Department of Dermatology,The First Hospital of China Medical University, Shenyang 110001,Liaoning,China;2.Department of Dermatology, The Fourth Hospital of Jilin University;3.Department of Dermatology, People’s Hospital of Henan Province) Abstract: Objective To investigate the effect of topical resveratrol on skin erythema induced by solar simulator ultraviolet irradiation. Methods Twenty volunteers were recruited and 6 experimental sites were separately marked on their bilateral backs. Sites 1 to 4 were topically applied with resveratrol combination with antioxidant, antioxidant, resveratrol, base, respectively. The products were applied to left-side followed by irradiation, and the products were applied to right-side after irradiation. Sites 5 and site 6 were separatedly designated as positive control and negative control sites. The irradiation last 4 days and skin erythema was observed. Results On the 1st and 2nd days after irradiation, no or only slight erythema were observed on site 1 to site 3. On the 3rd and 4th days, the erythema of site 1 and site 3 remained unchanged comparing to that on the 2nd day, whereas the erythema of site 2 became obvious than before and lighter than that of site 5. The erythema on left-side is slighter than that on right-side. Conclusion Topical resveratol could effectively prevent (more obviously) and reverse the skin erythema induced by solar simulator ultraviolet irradiation. Key