韦荣球菌与龋病和链球菌间的关系-国际口腔医学杂志.pdfVIP

44  2 2017  3 •195• 国际口腔医学杂志 第 卷 期 年 月 韦荣球菌与龋病和链球菌间的关系 王玉霞 周学东 李明云 口腔疾病研究国家重点实验室 华西口腔医院牙体牙髓病科（四川大学） 成都 610041 [摘要] 韦荣球菌为口腔微生态的重要成员之一，在人类口腔中呈高丰度分布。韦荣球菌不能代谢糖产酸，但能 代谢乳酸，这一点曾被认为对龋病的发生发展有抑制作用，但体外及动物试验对于韦荣球菌在龋病发生中的作用 及其机制并未得出明确结论。近来随着口腔微生物组学研究的发展，人们发现，韦荣球菌在龋活跃者口腔中的分 布较无龋者高，韦荣球菌与多种致龋菌分布呈高度相关性，韦荣球菌对变异链球菌等致龋菌有促进作用。龋病是 多种微生物共同作用的结果，而韦荣球菌作为龋病相关因素不容忽视。本文就韦荣球菌在口腔中的分布、韦荣球 菌与龋病的关系、韦荣球菌与链球菌的相互作用等研究进展作一综述，以剖析韦荣球菌在龋病发生发展中的作用 及其机制。 [关键词] 韦荣球菌； 链球菌； 龋病 [中图分类号] R 780.2 [文献标志码] A [doi] 10.7518/gjkq.2017.02.016 A review on the role of Veillonella in caries and its interaction with Streptococcus Wang Yuxia, Zhou Xuedong, Li Mingyun. (State Key Laboratory of Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) This study was supported by the National Natural Science Foundation of China and the International Science and Technology Cooperation Program of China(2014DFE30180). [Abstract] The genus Veillonella is a member of the normal oral flora and is highly abundant in the human oral cavity. Veillonella utilizes lactate, which ameliorates the caries process. However, results of in vitro studies and rat model systems are ambiguous. With the development of human oral microbiome research, several studies reported that the frequency of Veillonella in caries-activated individuals is higher than that in caries-free ones, and the distribution of Veillonella is highly related to some cariogenic Streptococcus species. Veillonella facilitates the action of some cariogenic Streptococcus species, such as Streptococcus mutans in caries development. These