atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin过敏性dermatitis-like相关疾病和致命的骨髓增生障碍来自小鼠皮肤切口信号的损失.pdfVIP

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin 1. ´ 1. 1 1 1 ` Alexis Dumortier , Andre-Dante Durham , Matteo Di Piazza , Sophie Vauclair , Ute Koch , Gisele 1 2 3 4 5 6 Ferrand , Isabel Ferrero , Shadmehr Demehri , Lynda Li Song , Andrew G. Farr , Warren J. Leonard , 3 4 7 8 1 Raphael Kopan , Lucio Miele , Daniel Hohl , Daniela Finke , Freddy Radtke * ´ ´ 1 Ecole Polytechnique Federale de Lausanne (EPFL SV ISREC), Lausanne, Switzerland, 2 Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland, 3 Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Chicago, Illinois, United States of America, 5 Department of Biological Structure and Department of Immunology, University of Washington, Seattle, Washington, United States of America, 6 Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 7 Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 8 Center for Biomedicine, Department of Clinical and Biological Sciences (DKBW), University of Basel, Basel, Switzerland Abstract Background: The Notch pathway