ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over ifn-α in htlv-1-associated myelopathy抗坏血酸的体外抗增殖,细胞death-inducing和免疫调节效应在ifn-αhtlv-1-associated脊髓病.pdfVIP

Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-a in HTLV-1-Associated Myelopathy 1 2¤a 1 1,2 ´ Britta Moens *, Daniele Decanine , Soraya Maria Menezes , Ricardo Khouri , Gilvaneia Silva- 2¤b 3 1,3 3 3,4 Santos , Giovanni Lopez , Carolina Alvarez , Michael Talledo , Eduardo Gotuzzo , Ramon de 5 ˜ 2,5 1,6 Almeida Kruschewsky , Bernardo Galvao-Castro , Anne-Mieke Vandamme , Johan Van Weyenbergh1,2 1 Rega Institute for Medical Research, K. U. Leuven, Leuven, Belgium, 2 Gonc¸alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador-Bahia, Brazil, 3 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, 4 Departamento de Medicina, Facultad de Medicina, ´ Universidad Peruana Cayetano Heredia, Lima, Peru, 5 Bahia School of Medicine and Public Health, Salvador-Bahia, Brazil, 6 Centro de Malaria e outras Doenc¸as Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal Abstract Background: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind con