brain phenotype of transgenic mice overexpressing cystathionine β-synthase转基因小鼠的大脑表型overexpressing胱硫醚β-synthase.pdfVIP

Brain Phenotype of Transgenic Mice Overexpressing Cystathionine b-Synthase ´ 1 ¤ 2 3 2 ´ 1 Vinciane Regnier * , Jean-Marie Billard , Sapna Gupta , Brigitte Potier , Stephanie Woerner , Evelyne 1 ´ 1 4 4 4 5 Paly , Aurelie Ledru , Sabrina David , Sabrina Luilier , Jean-Charles Bizot , Guido Vacano , Jan P. 6 5 3 1 1 Kraus , David Patterson , Warren D. Kruger , Jean M. Delabar , Jaqueline London ´ ´ ´ 1 Unite de Biologie Fonctionnelle et Adaptative, CNRS EAC 4413, Universite Paris Diderot, Sorbonne Paris Cite, Paris, France, 2 Centre de Psychiatrie et Neurosciences, ´ ´ INSERM UMR 894, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France, 3 Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United ´ States of America, 4 Key-Obs SAS, Orleans, France, 5 The Eleanor Roosevelt Institute and the Department of Biological Sciences, University of Denver, Denver, Colorado, United States of America, 6 Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America Abstract Background: The cystathionine b-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes