betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo倍他司汀产生剂量依赖性影响耳蜗血管纹vascularis在豚鼠体内血液流动.pdfVIP

Betahistine Exerts a Dose-Dependent Effect on Cochlear Stria Vascularis Blood Flow in Guinea Pigs In Vivo 1,2,3 3 3 3,4 2,5. Fritz Ihler , Mattis Bertlich , Kariem Sharaf , Sebastian Strieth , Michael Strupp , 1,2,3 . Martin Canis * ¨ 1 Department of Otorhinolaryngology, Head and Neck Surgery, Goettingen University Medical School, Gottingen, Germany, 2 Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders, University of Munich Hospital, Munich, Germany, 3 Walter Brendel Centre of Experimental Medicine, University of Munich Hospital, Munich, Germany, 4 Department of Otorhinolaryngology, Head Neck Surgery, J. W. Goethe-University-Medical School, Frankfurt/Main, Germany, 5 Department of Neurology, University of Munich Hospital, Munich, Germany Abstract ` Objective: Betahistine is a histamine H -receptor agonist and H -receptor antagonist that is administered to treat Meniere’s 1 3 disease. Despite widespread use, its pharmacological mode of action has not been entirely elucidated. This study investigated the effect of betahistine on guinea pigs at dosages corresponding to clinically used doses for cochlear microcirculation. Methods: Thirty healthy Dunkin-Hartley guinea pigs were randomly assigned to five