brain serotonin synthesis in adult males characterized by physical aggression during childhood a 21-year longitudinal study在成年男性大脑5 -羟色胺合成的特点是物理攻击在儿童时期21年纵向研究.pdfVIP

Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study 1¤ 2,3,4,5,6 1,7,8 ´ 5,6 5,9 Linda Booij , Richard E. Tremblay , Marco Leyton , Jean R. Seguin , Frank Vitaro , Paul 1 1 ´ ´ 1 1 7,8 Gravel , Elisabeth Perreau-Linck , Melissa L. Levesque , France Durand , Mirko Diksic , Gustavo Turecki10, Chawki Benkelfat1,7,8* 1 Department of Psychiatry, McGill University, Montreal, Canada, 2 Departments of Psychology and Pediatrics, University of Montreal, Montreal, Canada, 3 School of Public Health and Population Sciences, University College, Dublin, Ireland, 4 INSERM U669, Paris, France, 5 Sainte-Justine Hospital Research Center, Montreal, Canada, 6 Department of Psychiatry, University of Montreal, Montreal, Canada, 7 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada, 8 McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada, 9 School of Psycho-Education, University of Montreal, Montreal, Canada, 10 McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Canada Abstract Background: Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait. Methodology/Principal Findings: In the present study, positron emission tomography with the tracer alpha-[