brain viscoelasticity alteration in chronic-progressive multiple sclerosis大脑粘弹性改变chronic-progressive多发性硬化症.pdfVIP

Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis 1 1 1 ¨ 2 ¨ 3 Kaspar-Josche Streitberger , Ingolf Sack *, Dagmar Krefting , Caspar Pfuller , Jurgen Braun , Friedemann Paul2,5., Jens Wuerfel2,4. ´ 1 Department of Radiology, Charite – University Medicine Berlin, Berlin, Germany, 2 NeuroCure Clinical Research Center and Experimental and Clinical Research Center, ´ ´ Charite – University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 3 Institute of Medical Informatics, Charite – University Medicine ´ Berlin, Berlin, Germany, 4 Institute of Neuroradiology, University Luebeck, Luebeck, Germany, 5 Clinical and Experimental Multiple Sclerosis Research Center, Charite - University Medicine Berlin, Berlin, Germany Abstract Introduction: Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressive disease courses of MS. Methods: We determined viscoelastic parameters of the brain