cardiac myosin binding protein c and map-kinase activating death domain-containing gene polymorphisms and diastolic heart failure心脏肌球蛋白结合蛋白c和map激酶激活死亡domain-containing基因多态性和舒张期心衰.pdfVIP

Cardiac Myosin Binding Protein C and MAP-Kinase Activating Death Domain-Containing Gene Polymorphisms and Diastolic Heart Failure 1,2. 3. 4,5,6 1 2,3 Cho-Kai Wu , Yin-Tsen Huang , Jen-Kuang Lee , Liang-Ting Chiang , Fu-Tien Chiang , Shu- 7 1 1 8 1 Wei Huang , Jiunn-Lee Lin , Chuen-Den Tseng , Yau-Hung Chen *, Chia-Ti Tsai * 1 Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, 2 Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 3 Department of Family Medicine and Health Management Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan, 4 Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan, 5 Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, 6 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 7 Graduate Institute of Biomedical Engineering, College of Medicine, National Yang-Ming University, Taipei, Taiwan, 8 Department of Chemistry, Tamkang University, Tamsui, Taiwan Abstract Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study. Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and i