原创力文档cellular immunity confers transient protection in experimental buruli ulcer following bcg or mycolactone-negative mycobacterium ulcerans vaccination细胞免疫授予瞬态保护实验布鲁里溃疡卡介苗或mycolactone-negative溃疡分枝杆菌疫苗接种后.pdfVIP
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cellular immunity confers transient protection in experimental buruli ulcer following bcg or mycolactone-negative mycobacterium ulcerans vaccination细胞免疫授予瞬态保护实验布鲁里溃疡卡介苗或mycolactone-negative溃疡分枝杆菌疫苗接种后
Cellular Immunity Confers Transient Protection in
Experimental Buruli Ulcer following BCG or Mycolactone-
Negative Mycobacterium ulcerans Vaccination
1,2 1,2 ´ 1¤ 3 4
Alexandra G. Fraga , Teresa G. Martins , Egıdio Torrado , Kris Huygen , Franc¸oise Portaels ,
5 ´ 1,2 1,2
Manuel T. Silva , Antonio G. Castro , Jorge Pedrosa *
1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 2 ICVS/3B’s - PT Government Associate Laboratory,
˜
Braga/Guimaraes, Portugal, 3 Scientific Service Immunology, Scientific Institute of Public Health WIV-ISP (Site Ukkel), Brussels, Belgium, 4 Mycobacteriology Unit,
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium, 5 Institute for Molecular and Cell Biology, Porto, Portugal
Abstract
Background: Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcerans that can result in
extensive necrotizing cutaneous lesions due to the cytotoxic exotoxin mycolactone. There is no specific vaccine against BU
but reports show some degree of cross-reactive protection conferred by M. bovis BCG immunization. Alternatively, an M.
ulcerans-specific immunization could be a better preventive strategy.
Methodology/Principal Findings: In this study, we used the mouse model to characterize the histological and cytokine
profiles triggered by vaccination with either BCG or mycolactone-negative M. ulcerans, followed by footpad infection with
virulent M. ulcerans. We observed that BCG vaccination significantly delayed the onset of M. ulcerans growth and f
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