changes in the diurnal rhythms during a 45-day head-down bed rest昼夜节律的变化在45天的头卧床休息.pdfVIP

Changes in the Diurnal Rhythms during a 45-Day Head- Down Bed Rest 1 1 1 1 1 2 2 Xiaodi Liang , Lin Zhang , Yufeng Wan , Xinyang Yu , Yiming Guo , Xiaoping Chen , Cheng Tan , 1 1 1 1 2 3 2 Tianle Huang , Hanjie Shen , Xianyun Chen , Hongying Li , Ke Lv , Fei Sun , Shanguang Chen , Jinhu Guo1* 1 Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China, 2 State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Centre, Beijing, China, 3 School of Life Sciences, University of Science and Technology of China, and Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China Abstract In spaceflight human circadian rhythms and sleep patterns are likely subject to change, which consequently disturbs human physiology, cognitive abilities and performance efficiency. However, the influence of microgravity on sleep and circadian clock as well as the underlying mechanisms remain largely unknown. Placing volunteers in a prone position, whereby their heads rest at an angle of 26u below horizontal, mimics the microgravity environment in orbital flight. Such positioning is termed head-down bed rest (HDBR). In this work, we analysed the influence of a 45-day HDBR on physiological diurnal rhythms. We examined urinary electrolyte and hormone excretion, and the results show a dramatic elevation of cortisol levels during HDBR and recovery. Increased diuresis, melatonin and testosterone were observed at certain periods during