class ii transactivator (ciita) enhances cytoplasmic processing of hiv-1 pr55gag二级反式激活因子(ciita)提高hiv - 1 pr55gag胞质处理.pdfVIP

Class II Transactivator (CIITA) Enhances Cytoplasmic Processing of HIV-1 Pr55Gag Kristen A. Porter, Lauren N. Kelley, Annette George, Jonathan A. Harton, Karen M. Duus* Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America Abstract Background: The Pr55gag (Gag) polyprotein of HIV serves as a scaffold for virion assembly and is thus essential for progeny virion budding and maturation. Gag localizes to the plasma membrane (PM) and membranes of late endosomes, allowing for release of infectious virus directly f