clonal characterization of rat muscle satellite cells proliferation, metabolism and differentiation define an intrinsic heterogeneity克隆鉴定大鼠肌卫星细胞的增殖、代谢和分化定义一个内在异质性.pdfVIP

Clonal Characterization of Rat Muscle Satellite Cells: Proliferation, Metabolism and Differentiation Define an Intrinsic Heterogeneity 1,2 1 1 1,3 2,4 Carlo A. Rossi , Michela Pozzobon , Andrea Ditadi , Karolina Archacka , Annalisa Gastaldello , 5 5 2 5 2 6 Marta Sanna , Chiara Franzin , Alberto Malerba , Gabriella Milan , Mara Cananzi , Stefano Schiaffino , 4,7 5 1,2 Michelangelo Campanella *, Roberto Vettor , Paolo De Coppi * 1 Stem Cell Processing Laboratory, Department of Pediatrics, University of Padua, Padova, Italy, 2 Surgery Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, London, United Kingdom, 3 Department of Cytology, Faculty of Biology, University of Warsaw, Warsaw, Poland, 4 Royal Veterinary College, University of London, London, United Kingdom, 5 Endocrine-metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padua, Padova, Italy, 6 Venetian Institute of Molecular Medicine, Padova, Italy, 7 Consortium for Mitochondrial Research, University College London, London, United Kingdom Abstract Satellite cells (SCs) represent a distinct lineage of myogenic progenitors responsible for the postnatal growth, repair and maintenance of skeletal muscle. Distinguished on the basis of their unique position in mature skeletal muscle, SCs were considered unipotent stem cells with the ability of generating a unique specialized phenotype. Su